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South Florida's
FRONT PAGE: February 23, 2006 print edition
Take This Research to Heart
Some types of cholesterol pose larger risks than others
Your cholesterol test is back and your number is normal:
under 200. Breathing easier? Not so fast. You still
might be at risk for clogged blood vessels and heart attack.
Researchers have identified at least 17 types of cholesterol
-- seven kinds of "bad cholesterol" -- and are
starting to clarify which are most dangerous. At the same
time, new tests better pinpoint which types you have.
As a result, some patients with normal readings on standard
cholesterol tests might have elevated risk of heart disease
if they have high levels of the more damaging
kinds, doctors say. They can start taking cholesterol-
lowering drugs.
Bottom line: Knowing your total cholesterol number isn't
enough.
"The cholesterol number that everyone talks about on TV and
at parties isn't that helpful, really," said
Boca
Raton cardiologist
Seth Baum.
"It doesn't tell you anything about the cholesterol you
have."
Even those who know their "bad cholesterol" number
(measuring low-density lipoprotein, or LDL) and "good
cholesterol" number (high-density lipoprotein, or HDL)
may not have a full picture. Some researchers say normal LDL
and HDL numbers may mask those needing treatment.
"Those are not always very accurate either," said Dr. Jere
Segrest, director of atherosclerosis research at the
University of Alabama at Birmingham. "More people
probably need to be taking medication."
Scientists agree that the latest research better explains
how and why high cholesterol is a risk, which is crucial in
a nation where one in three people have cholesterol levels
above 200, borderline for risk. At least 42 million
have levels over 240, putting them at high risk, according
to the U.S. Centers for Disease Control and
Prevention.
Research in recent years has clearly linked fat-laden
cholesterol with buildup of plaque in blood vessels, which
can narrow, block blood flow and trigger heart attacks.
Since 1994, studies have shown statin drugs such as Lipitor
and Zocor lower cholesterol and prevent heart attacks.
Statins now are the nation's top-selling medicine with $15.9
billion in sales and 144 million prescriptions as of last
year, according to IMS, a pharmaceutical tracking company.
But half of heart attack victims have normal cholesterol
levels, suggesting to some experts that there's
more to know about its link to heart disease. The bad kind,
LDL, has at least seven varieties ranging from large
particles of fluffy fat to small particles of
dense fat. All are harmful, but small, dense LDL are proving
to be the worst.
A study reported in the American Journal of Cardiology
found that people with small dense particles were 3 to
4.5 times more likely to have heart disease and 6.9 times
more likely to have heart attacks than those with normal
numbers. Segrest said small particles may stick to artery
walls more easily, starting blockages.
HDL has five varieties, considered helpful because they
carry bad cholesterol from the blood to be
destroyed in the liver. Some studies show the largest and
fluffiest varieties of HDL are most protective.
Segrest and others say people with normal LDL and HDL
numbers may be at risk, if they have high amounts of small,
dense types. A cholesterol blood test called VAP --
Vertical Auto Profile -- can break down a person's
cholesterol.
"It would be worth doing once as a baseline to know where
you stand," said Segrest, a paid consultant for the test's
maker, Atherotech. "I'm not sure it's worth the
money to test everyone. But people may benefit from
knowing."
Other doctors, including Baum, think the number of
cholesterol particles is the key, not the size. The
more particles, the more damage to linings of arteries.
"We've had people who have changed [treatment] completely
after seeing this," said Baum, who has been paid to lecture
on behalf of a competing test maker,
LipoScience.
The new tests are catching on and growing, now given to more
than two million people a year, mainly those at high risk.
Some scientists are not convinced that the new approaches
are necessary or better than LDL or HDL numbers. The
evidence is strong but "not ironclad" that analyzing
cholesterol particle size and counts improves detection and
treatment, said Dr. Scott Grundy, who chairs the National
Institutes of Health panel that set the country's
cholesterol guidelines.
Grundy said he uses the more specialized cholesterol tests
for patients at high risk or with family history of heart
disease, and has detected patients not known to have high
cholesterol. But it's probably too early to use specialized
tests to screen the general public, said Grundy, a
University of Texas nutrition expert who has written
position papers on cholesterol for the
American Heart Association and the American College of
Cardiology.
"We're not sure how to use those numbers yet. It's not so
simple," Grundy said.
Also, some fear that doctors may lean too much on the
more-detailed cholesterol tests and overprescribe statin
drugs, which can cause liver damage in some patients. Plus,
the detailed tests cost $90 to $160, compared to a basic
test costing $15 to $50.
"These new technologies are potentially important," said Dr.
Ronald B. Goldberg, director of lipid disorders at
University of Miami Diabetes Research Institute. "But to
this point, there is no clear evidence this information is
more accurate in identifying risk for heart disease."
For now, Grundy said patients can follow NIH cholesterol
guidelines: LDL below 70 for high-risk people with past
heart trouble or many risk factors, below 100 for
moderate-risk people with two or more risk factors, and
below 160 for low-risk people.
For HDL, keep levels above 40, and 60 is better. Exercise,
eat healthy, quit smoking and lose weight if needed.
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